| # | Player | Team | G | ATT | YDS ▾ | Y/C | TD | FUM | EPA |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Saquon Barkley | PHI | 16 | 345 | 2005 | 5.8 | 13 | 2 | 37.3 |
| 2 | Derrick Henry | BAL | 17 | 325 | 1921 | 5.9 | 16 | 3 | 40.6 |
| 3 | Bijan Robinson | ATL | 17 | 304 | 1456 | 4.8 | 14 | 1 | 17.9 |
| 4 | Jonathan Taylor | IND | 14 | 303 | 1431 | 4.7 | 11 | 2 | -22.9 |
| 5 | Jahmyr Gibbs | DET | 17 | 250 | 1412 | 5.6 | 16 | 0 | 35.1 |
| 6 | Josh Jacobs | GB | 17 | 301 | 1329 | 4.4 | 15 | 4 | -20.2 |
| 7 | Kyren Williams | LA | 16 | 316 | 1299 | 4.1 | 14 | 5 | -23.5 |
| 8 | Chuba Hubbard | CAR | 15 | 250 | 1195 | 4.8 | 10 | 1 | 10.7 |
| 9 | Aaron Jones | MIN | 17 | 255 | 1138 | 4.5 | 5 | 3 | -13.4 |
| 10 | Bucky Irving | TB | 17 | 207 | 1122 | 5.4 | 8 | 2 | 20.9 |
| 11 | James Conner | ARI | 16 | 236 | 1094 | 4.6 | 8 | 2 | 1.2 |
| 12 | Tony Pollard | TEN | 16 | 260 | 1079 | 4.2 | 5 | 2 | -26.2 |
| 13 | Rico Dowdle | DAL | 16 | 235 | 1079 | 4.6 | 2 | 3 | -10.5 |
| 14 | Najee Harris | PIT | 17 | 263 | 1043 | 4.0 | 6 | 0 | -17.0 |
| 15 | Joe Mixon | HOU | 14 | 245 | 1016 | 4.1 | 11 | 0 | -15.1 |
| 16 | James Cook | BUF | 16 | 207 | 1009 | 4.9 | 16 | 1 | 10.6 |
| 17 | Chase Brown | CIN | 16 | 229 | 990 | 4.3 | 7 | 2 | -4.8 |
| 18 | D'Andre Swift | CHI | 17 | 253 | 959 | 3.8 | 6 | 1 | -38.9 |
| 19 | Alvin Kamara | NO | 14 | 228 | 950 | 4.2 | 6 | 0 | -18.2 |
| 20 | Lamar Jackson | BAL | 17 | 139 | 915 | 6.6 | 4 | 6 | 11.7 |
| 21 | Devon Achane | MIA | 17 | 203 | 907 | 4.5 | 6 | 0 | -11.3 |
| 22 | J.K. Dobbins | LAC | 13 | 195 | 905 | 4.6 | 9 | 0 | 4.2 |
| 23 | Jayden Daniels | WAS | 17 | 148 | 891 | 6.0 | 6 | 3 | 58.5 |
| 24 | Breece Hall | NYJ | 16 | 209 | 876 | 4.2 | 5 | 5 | -20.9 |
| 25 | Tyrone Tracy | NYG | 17 | 192 | 839 | 4.4 | 5 | 2 | -20.7 |
| 26 | Rhamondre Stevenson | NE | 15 | 207 | 801 | 3.9 | 7 | 6 | -37.9 |
| 27 | Brian Robinson | WAS | 14 | 187 | 799 | 4.3 | 8 | 2 | -12.1 |
| 28 | Jordan Mason | SF | 12 | 153 | 789 | 5.2 | 3 | 3 | -5.4 |
| 29 | David Montgomery | DET | 14 | 185 | 775 | 4.2 | 12 | 2 | -8.8 |
| 30 | Tank Bigsby | JAX | 16 | 168 | 766 | 4.6 | 7 | 3 | -0.8 |
| 31 | Kareem Hunt | KC | 13 | 200 | 728 | 3.6 | 7 | 0 | 2.1 |
| 32 | Tyler Allgeier | ATL | 17 | 137 | 644 | 4.7 | 3 | 0 | 5.5 |
| 33 | Jalen Hurts | PHI | 15 | 150 | 630 | 4.2 | 14 | 4 | 40.7 |
| 34 | Rachaad White | TB | 15 | 144 | 613 | 4.3 | 3 | 2 | -15.7 |
| 35 | Kenneth Walker | SEA | 11 | 153 | 573 | 3.7 | 7 | 1 | -12.1 |
| 36 | Kyler Murray | ARI | 17 | 78 | 572 | 7.3 | 5 | 4 | 17.9 |
| 37 | Zach Charbonnet | SEA | 17 | 135 | 569 | 4.2 | 8 | 0 | -11.3 |
| 38 | Jerome Ford | CLE | 14 | 104 | 565 | 5.4 | 3 | 0 | 5.0 |
| 39 | Travis Etienne | JAX | 15 | 150 | 558 | 3.7 | 2 | 1 | -26.6 |
| 40 | Antonio Gibson | NE | 17 | 120 | 538 | 4.5 | 1 | 2 | -10.7 |
| 41 | Josh Allen | BUF | 16 | 102 | 531 | 5.2 | 12 | 0 | 57.0 |
| 42 | Javonte Williams | DEN | 17 | 139 | 513 | 3.7 | 4 | 2 | -23.9 |
| 43 | Jaylen Warren | PIT | 15 | 120 | 511 | 4.3 | 1 | 1 | -14.2 |
| 44 | Emanuel Wilson | GB | 17 | 103 | 502 | 4.9 | 4 | 0 | 9.2 |
| 45 | Anthony Richardson | IND | 11 | 86 | 499 | 5.8 | 6 | 6 | 23.8 |
| 46 | Jaleel McLaughlin | DEN | 16 | 113 | 496 | 4.4 | 1 | 0 | -1.0 |
| 47 | Caleb Williams | CHI | 17 | 81 | 489 | 6.0 | 0 | 3 | 11.6 |
| 48 | Cam Akers | MIN | 16 | 104 | 444 | 4.3 | 2 | 1 | -18.5 |
| 49 | Ray Davis | BUF | 17 | 113 | 442 | 3.9 | 3 | 0 | -5.6 |
| 50 | Devin Singletary | NYG | 15 | 113 | 437 | 3.9 | 4 | 2 | -11.1 |
333 players