| # | Player | Team | W | L | SV | G | GS | IP | SO ▾ | K/9 | BB/9 | ERA | FIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jacob Misiorowski | MIL | 10 | 4 | 0 | 18 | 18 | 111.0 | 167 | 13.5 | 2.2 | 1.62 | — | — |
| 2 | Dylan Cease | TOR | 6 | 4 | 0 | 17 | 17 | 98.1 | 148 | 13.5 | 4.0 | 2.56 | — | — |
| 3 | Cristopher Sánchez | PHI | 10 | 4 | 0 | 19 | 19 | 120.1 | 137 | 10.2 | 1.8 | 2.62 | — | — |
| 4 | Jesús Luzardo | PHI | 8 | 4 | 0 | 19 | 19 | 110.1 | 136 | 11.1 | 2.9 | 3.51 | — | — |
| 5 | Gavin Williams | CLE | 10 | 4 | 0 | 19 | 19 | 113.1 | 134 | 10.6 | 2.9 | 3.81 | — | — |
| 6 | Cam Schlittler | NYY | 9 | 5 | 0 | 19 | 19 | 112.0 | 131 | 10.5 | 1.7 | 2.01 | — | — |
| 7 | Paul Skenes | PIT | 7 | 8 | 0 | 19 | 19 | 103.0 | 123 | 10.7 | 2.0 | 3.58 | — | — |
| 8 | Nolan McLean | NYM | 6 | 5 | 0 | 19 | 19 | 105.1 | 123 | 10.5 | 3.3 | 3.59 | — | — |
| 9 | Reid Detmers | LAA | 3 | 6 | 0 | 19 | 19 | 108.2 | 123 | 10.2 | 2.9 | 4.39 | — | — |
| 10 | Joe Ryan | MIN | 6 | 5 | 0 | 19 | 19 | 104.1 | 122 | 10.5 | 2.0 | 2.85 | — | — |
| 11 | Braxton Ashcraft | PIT | 9 | 3 | 0 | 18 | 18 | 108.1 | 122 | 10.1 | 2.1 | 3.24 | — | — |
| 12 | Jacob deGrom | TEX | 7 | 5 | 0 | 18 | 18 | 100.2 | 122 | 10.9 | 2.0 | 3.49 | — | — |
| 13 | Nathan Eovaldi | TEX | 9 | 7 | 0 | 18 | 18 | 111.1 | 120 | 9.7 | 2.1 | 4.04 | — | — |
| 14 | Chase Burns | CIN | 11 | 1 | 0 | 18 | 18 | 102.2 | 118 | 10.3 | 3.2 | 2.54 | — | — |
| 15 | Chris Sale | ATL | 9 | 6 | 0 | 17 | 17 | 98.0 | 117 | 10.7 | 2.3 | 2.20 | — | — |
| 16 | Max Meyer | MIA | 9 | 1 | 0 | 19 | 19 | 108.0 | 116 | 9.7 | 3.2 | 2.58 | — | — |
| 17 | José Soriano | LAA | 8 | 5 | 0 | 19 | 19 | 106.0 | 115 | 9.8 | 4.3 | 3.40 | — | — |
| 18 | Logan Gilbert | SEA | 7 | 5 | 0 | 18 | 18 | 107.1 | 114 | 9.6 | 1.8 | 3.19 | — | — |
| 19 | Sean Burke | CWS | 5 | 4 | 0 | 19 | 15 | 104.2 | 113 | 9.7 | 2.8 | 3.35 | — | — |
| 20 | Taj Bradley | MIN | 8 | 3 | 0 | 17 | 17 | 95.2 | 112 | 10.5 | 3.6 | 3.67 | — | — |
| 21 | MacKenzie Gore | TEX | 5 | 8 | 0 | 19 | 19 | 101.0 | 111 | 9.9 | 3.6 | 4.72 | — | — |
| 22 | Parker Messick | CLE | 7 | 5 | 0 | 19 | 19 | 112.0 | 110 | 8.8 | 2.9 | 2.73 | — | — |
| 23 | Foster Griffin | WSH | 10 | 2 | 0 | 19 | 19 | 110.1 | 109 | 8.9 | 2.1 | 2.77 | — | — |
| 24 | Kevin Gausman | TOR | 4 | 8 | 0 | 19 | 19 | 106.1 | 108 | 9.1 | 2.5 | 4.32 | — | — |
| 25 | Cade Cavalli | WSH | 5 | 4 | 0 | 19 | 19 | 92.2 | 105 | 10.2 | 3.0 | 3.88 | — | — |
| 26 | Shota Imanaga | CHC | 5 | 7 | 0 | 19 | 19 | 108.0 | 105 | 8.8 | 2.3 | 4.17 | — | — |
| 27 | Ryan Weathers | NYY | 3 | 7 | 0 | 18 | 18 | 93.1 | 105 | 10.1 | 2.6 | 4.24 | — | — |
| 28 | Landen Roupp | SF | 6 | 8 | 0 | 18 | 18 | 97.0 | 104 | 9.6 | 3.9 | 4.27 | — | — |
| 29 | Bryan Woo | SEA | 7 | 6 | 0 | 18 | 18 | 104.1 | 102 | 8.8 | 1.7 | 4.23 | — | — |
| 30 | Aaron Nola | PHI | 3 | 6 | 0 | 19 | 19 | 97.0 | 102 | 9.5 | 2.9 | 5.75 | — | — |
| 31 | Kyle Harrison | MIL | 8 | 2 | 0 | 17 | 17 | 83.2 | 101 | 10.9 | 2.2 | 3.01 | — | — |
| 32 | Kyle Bradish | BAL | 5 | 9 | 0 | 18 | 18 | 100.2 | 101 | 9.0 | 4.3 | 3.75 | — | — |
| 33 | Yoshinobu Yamamoto | LAD | 9 | 5 | 0 | 16 | 16 | 104.2 | 100 | 8.6 | 1.8 | 2.49 | — | — |
| 34 | Sandy Alcantara | MIA | 10 | 4 | 0 | 20 | 20 | 130.2 | 100 | 6.9 | 2.3 | 3.99 | — | — |
| 35 | Zack Wheeler | PHI | 9 | 1 | 0 | 14 | 14 | 87.0 | 98 | 10.1 | 2.1 | 2.28 | — | — |
| 36 | Drew Rasmussen | TB | 7 | 5 | 0 | 18 | 18 | 99.1 | 98 | 8.9 | 1.5 | 3.26 | — | — |
| 37 | George Kirby | SEA | 7 | 8 | 0 | 18 | 18 | 110.0 | 98 | 8.0 | 2.0 | 3.76 | — | — |
| 38 | Jack Flaherty | DET | 3 | 8 | 0 | 18 | 18 | 82.1 | 98 | 10.7 | 4.4 | 4.48 | — | — |
| 39 | Freddy Peralta | NYM | 5 | 7 | 0 | 19 | 19 | 100.0 | 98 | 8.8 | 3.5 | 4.68 | — | — |
| 40 | Ranger Suarez | BOS | 4 | 3 | 0 | 17 | 17 | 91.1 | 97 | 9.6 | 2.6 | 3.15 | — | — |
| 41 | Michael Wacha | KC | 5 | 7 | 0 | 19 | 19 | 119.1 | 96 | 7.2 | 2.6 | 3.77 | — | — |
| 42 | Joey Cantillo | CLE | 7 | 4 | 0 | 19 | 19 | 96.0 | 96 | 9.0 | 4.4 | 3.66 | — | — |
| 43 | Shohei Ohtani | LAD | 8 | 2 | 0 | 14 | 14 | 85.2 | 95 | 10.0 | 2.7 | 1.79 | — | — |
| 44 | Will Warren | NYY | 7 | 4 | 0 | 18 | 18 | 93.1 | 94 | 9.1 | 3.0 | 4.15 | — | — |
| 45 | Connelly Early | BOS | 7 | 5 | 0 | 17 | 17 | 91.2 | 93 | 9.1 | 3.3 | 3.44 | — | — |
| 46 | Davis Martin | CWS | 9 | 4 | 0 | 18 | 18 | 100.1 | 92 | 8.3 | 2.8 | 3.41 | — | — |
| 47 | Emerson Hancock | SEA | 6 | 4 | 0 | 17 | 17 | 97.2 | 92 | 8.5 | 2.2 | 3.23 | — | — |
| 48 | Michael King | SD | 6 | 7 | 0 | 19 | 19 | 108.1 | 92 | 7.6 | 3.6 | 3.41 | — | — |
| 49 | Shane Baz | BAL | 4 | 9 | 0 | 18 | 18 | 107.0 | 90 | 7.6 | 3.5 | 4.21 | — | — |
| 50 | Eury Pérez | MIA | 5 | 6 | 0 | 15 | 15 | 79.2 | 89 | 10.1 | 3.6 | 3.84 | — | — |
743 players